# Sermorelin Before and After in the Studies: The Measured GH/IGF-1 Changes > Sermorelin before and after — the actual measured changes from GHRH(1-29) studies: older-men GH/IGF-1 reversal, pediatric growth velocity, body composition. Cited. The measured changes — what moved, by how much, and over what timeframe — pulled straight from the trials. ## The short version When people search **sermorelin before and after**, they usually want photos. This page gives something more reliable: the before-and-after *numbers* the studies actually recorded. No clinic, no marketing pictures — just the measured changes. The clearest before-and-after is in older men: after two weeks of GHRH(1-29), their growth hormone and IGF-1 went from an age-lowered level back to a level that matched young men's [2]. In growth-hormone-deficient children, growth speed roughly doubled in the first year [1]. And in older adults, a longer-acting GHRH cousin (tesamorelin) cut body fat by 7.4% and nudged cognition over 20 weeks [7]. Those are the honest before-and-afters. Where the long-term picture is still blank, we say so. ## Before and after in older men: the axis moved back The most-cited sermorelin before-and-after is the aging-axis reversal. In healthy older men (mean age 68), the *before* picture was the typical age-related decline in growth hormone and IGF-1. The *after* picture, following 0.5 mg and 1 mg of GHRH(1-29) twice daily for 14 days, was a dose-related rise in 24-hour GH and IGF-1 — and at the high dose, those measures no longer differed from young men's [2]. Fasting blood sugar did not change [2]. In plain terms: a two-week course moved an aging lab profile back toward a younger one. That is a real, measured before-and-after on the hormone numbers. It is not a claim about how anyone looked or felt, and it does not prove the change lasts or produces long-term benefit — the study didn't follow that [2]. ## Before and after in children: growth roughly doubled The sturdiest before-and-after is in growth-hormone-deficient children. The *before* was a slow first-year growth rate of about 4.1 cm/year. The *after*, on once-daily subcutaneous sermorelin, was roughly 7-8 cm/year — without excessive IGF-1 generation [1]. That near-doubling of height velocity is the cleanest example of sermorelin producing a visible, real-world outcome rather than a lab-only shift, and it's the use sermorelin was approved for [1]. ## Before and after in body composition (via tesamorelin) The body-composition before-and-after that people often attribute to sermorelin actually comes from its stabilized cousin, tesamorelin. In a controlled trial of 152 older adults, 20 weeks of tesamorelin (1 mg/day before bed) reduced percent body fat by 7.4%, raised IGF-1 by 117% within the normal range, and had a favorable effect on cognition [7]. We attribute this to tesamorelin, not sermorelin, on purpose — it's a closely related GHRH analog studied for exactly these outcomes, and borrowing its results for sermorelin would overstate the record [7]. ## The honest 'after' that's still blank Not every before-and-after has an after yet. The two-week and 20-week studies are short. Rigorous long-term data on adult anti-aging use — months and years out — are limited, and a 2008 editorial concluded that secretagogue use for aging is "not yet ready for prime time" [5]. So the most honest before-and-after for long-term adult use is: *before* — an age-lowered GH/IGF-1 axis; *after* — we don't have the long-run controlled data to fill that cell in. Leaving it openly blank is more useful than guessing. --- A kitchen-table reading of the sermorelin record — every GHRH(1-29) figure explained in plain words and tied to the study that measured it, the body-composition data kept where it belongs as tesamorelin, and the spot where the long-term adult anti-aging evidence simply runs out left honestly empty; despite the 'shop' in the name there is no clinic, no vendor, and nothing here is dosed, dispensed, or sold.